In the frame of COP20 for the Barcelona Convention, the Mediterranean institutions and NGOs outline the Barcelona Commitment facing marine litter in the Mediterranean area for 2025. As citizens, citizen initiatives and NGOs, we call for waste prevention to reduce marine litter (in line with the Rio+20 §163 declaration, the Waste Hierarchy as outlined in the Waste Framework Directive and the Marine Strategy Framework Directive (MSFD) objectives). Mediterranean was first Regional Sea Programme to develop a Regional plan on the management of Marine Litter in 2013. In the context of the Barcelona Convention and Mediterranean UNEP/MAP, we see it urgent to move in a much more ambitious and dedicated way towards a “Mediterranean without Plastics”.